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1

Inhibition of the glycolytic enzymes in the trypanosome: An approach in the development of new leads in the therapy of parasitic diseases

Jacques Perie, Isabelle Riviere-Alric, Casimir Blonski, Thierry Gefflaut, Nancy Lauth de Viguerie, Murielle Trinquier, Michèle Willson, Fred R. Opperdoes, Mia Callens

Journal:

Pharmacology & Therapeutics

Year:

1993

Language:

english

File:

PDF, 1.10 MB

english, 1993

2

Pyruvate kinase of Leishmania mexicana mexicana Cloning and analysis of the gene, overexpression in Escherichia coli and characterization of the enzyme

Isabelle Ernest, Mia Callens, Fred R. Opperdoes, Paul A.M. Michels

Journal:

Molecular and Biochemical Parasitology

Year:

1994

Language:

english

File:

PDF, 950 KB

english, 1994

3

Metabolism of Leishmania: proven and predicted

Fred R. Opperdoes, Graham H. Coombs

Journal:

Trends in Parasitology

Year:

2007

Language:

english

File:

PDF, 1.38 MB

english, 2007

4

Changes in the phosphoproteome of brown adipose tissue during hibernation in the ground squirrel, Ictidomys tridecemlineatus

Vertommen, Didier, Herinckx, Gaetan, Hussain, Nusrat, Opperdoes, Fred, Storey, Kenneth B, Rider, Mark H.

Journal:

Physiological Genomics

Year:

2017

Language:

english

File:

PDF, 1.12 MB

english, 2017

5

Selektive Inhibierung der trypanosomalen Triosephosphat-Isomerase durch ein Thiopeptid

Prof. Dr. Horst Kessler, Hans Matter, Armin Geyer, Hans-Jürgen Diehl, Matthias Köck, Guido Kurz, Prof. Dr. Fred R. Opperdoes, Dr. Mia Callens, Dr. Rik K. Wierenga

Journal:

Angewandte Chemie

Year:

1992

Language:

german

File:

PDF, 410 KB

german, 1992

6

Selective Inhibition of Trypanosomal Triosephosphate Isomerase by a Thiopeptide

Prof. Dr. Horst Kessler, Dipl.-Chem. Hans Matter, Dipl.-Chem. Armin Geyer, Dipl.-Chem. Hans-Jürgen Diehl, Dipl.-Chem. Matthias Köck, Dipl.-Chem. Guido Kurz, Prof. Dr. Fred. R. Opperdoes, Dr. Mia Calle

Journal:

Angewandte Chemie International Edition

Year:

1992

Language:

english

File:

PDF, 468 KB

english, 1992

7

Miconazole: an inhibitor of cyanide-insensitive respiration in Trypanosoma brucei

Fred R. Opperdoes

Journal:

Transactions of the Royal Society of Tropical Medicine and Hygiene

Year:

1980

Language:

english

File:

PDF, 252 KB

english, 1980

8

Subcellular biochemistry (intracellular parasites, vol 18: J. L. Avila & J. R. Harris (editors). New York: Plenum Press, 1992. xxii + 450pp. Price US$95 · 00 in USA and Canada (US$114 · 00 elsewhere). ISBN 0-306-44065-2

Fred R. Opperdoes

Journal:

Transactions of the Royal Society of Tropical Medicine and Hygiene

Year:

1994

Language:

english

File:

PDF, 104 KB

english, 1994

9

Sequencing, Modeling, and Selective Inhibition of Trypanosoma brucei Hexokinase

Michèle Willson, Yves-Henri Sanejouand, Jacques Perie, Véronique Hannaert, Fred Opperdoes

Journal:

Chemistry & Biology

Year:

2002

Language:

english

File:

PDF, 544 KB

english, 2002

10

Kinetic characterization, structure modelling studies and crystallization of Trypanosoma brucei enolase

Véronique Hannaert, Marie-Astrid Albert, Daniel J. Rigden, M. Theresa da Silva Giotto, Otavio Thiemann, Richard C. Garratt, Joris Van Roy, Fred R. Opperdoes, Paul A. M. Michels

Journal:

Year:

2003

Language:

english

File:

PDF, 536 KB

english, 2003

11

Trypanosoma brucei contains a 2,3-bisphosphoglycerate independent phosphoglycerate mutase

Nathalie Chevalier, Daniel J. Rigden, Joris Van Roy, Fred R. Opperdoes, Paul A. M. Michels

Journal:

Year:

2000

Language:

english

File:

PDF, 1.05 MB

english, 2000

12

Glycerol kinase of Trypanosoma brucei : Cloning, molecular characterization and mutagenesis

Ivica Králová, Daniel J. Rigden, Fred R. Opperdoes, Paul A. M. Michels

Journal:

Year:

2000

Language:

english

File:

PDF, 1.40 MB

english, 2000

13

Evolution of energy metabolism and its compartmentation in Kinetoplastida

Véronique Hannaert, Frédéric Bringaud, Fred R Opperdoes, Paul AM Michels

Journal:

Kinetoplastid Biology and Disease

Year:

2003

Language:

english

File:

PDF, 2.07 MB

english, 2003

14

Structure of the complex between trypanosomal triosephosphate isomerase and N-hydroxy-4-phosphono-butanamide: Binding at the active site despite an “open” flexible loop conformation

Christophe L.M.J. Verlinde, Cornelis J. Witmans, Tjaard Pijning, Kor H. Kalk, Wim G.J. Hol, Mia Callens, Fred R. Opperdoes

Journal:

Protein Science

Year:

1992

Language:

english

File:

PDF, 711 KB

english, 1992

15

The crystal structure of the “open” and the “closed” conformation of the flexible loop of trypanosomal triosephosphate isomerase

Rik K. Wierenga, Martin E. M. Noble, Johan P. M. Postma, Hillie Groendijk, Kor H. Kalk, Wim G. J. Hol, Fred R. Opperdoes

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1991

Language:

english

File:

PDF, 1.69 MB

english, 1991

16

The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of three different complexes

Martin E. M. Noble, Rik K. Wierenga, Anne-Marie Lambeir, Fred R. Opperdoes, Andy-Mark W. H. Thunnissen, Kor H. Kalk, Hillie Groendijk, Wim G. J. Hol

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1991

Language:

english

File:

PDF, 1.63 MB

english, 1991

17

Molecular analysis of glyceraldehyde-3-phosphate dehydrogenase inTrypanoplasma borelli: An evolutionary scenario of subcellular compartmentation in Kinetoplastida

Erik A. C. Wiemer, Véronique Hannaert, Paul R. L. A. Ijssel, Joris Roy, Fred R. Opperdoes, Paul A. M. Michels

Journal:

Journal of Molecular Evolution

Year:

1995

Language:

english

File:

PDF, 1.32 MB

english, 1995

18

The trypanosomatidae: Amazing organisms

Fred R. Opperdoes

Journal:

Journal of Bioenergetics and Biomembranes

Year:

1994

Language:

english

File:

PDF, 200 KB

english, 1994

19

Comparison and Evolutionary Analysis of the Glycosomal Glyceraldehyde-3-Phosphate Dehydrogenase from Different Kinetoplastida

Véronique Hannaert, Fred R. Opperdoes, Paul A.M. Michels

Journal:

Journal of Molecular Evolution

Year:

1998

Language:

english

File:

PDF, 616 KB

english, 1998

20

Characterization of the ysa Pathogenicity Locus in the Chromosome of Yersinia enterocolitica and Phylogeny Analysis of Type III Secretion Systems

Boris Foultier, Paul Troisfontaines, Simone Müller, Fred R. Opperdoes, Guy R. Cornelis

Journal:

Journal of Molecular Evolution

Year:

2002

Language:

english

File:

PDF, 578 KB

english, 2002

21

Characterization of the cofactor-independent phosphoglycerate mutase from Leishmania mexicana mexicana : Histidines that coordinate the two metal ions in the active site show different susceptibilities to irreversible chemical modification

Daniel G. Guerra, Didier Vertommen, Linda A. Fothergill-Gilmore, Fred R. Opperdoes, Paul A. M. Michels

Journal:

Year:

2004

Language:

english

File:

PDF, 425 KB

english, 2004

22

Effects of Antimycin, Glucose Deprivation, and Serum on Cultures of Neurons, Astrocytes, and Neuroblastoma Cells

Petrus J. Pauwels, Fred R. Opperdoes, André Trouet

Journal:

Journal of Neurochemistry

Year:

1985

Language:

english

File:

PDF, 603 KB

english, 1985

23

Secretion of Sucrase by Leishmania donovani

J. JOSEPH BLUM, FRED R. OPPERDOES

Journal:

Journal of Eukaryotic Microbiology

Year:

1994

Language:

english

File:

PDF, 518 KB

english, 1994

24

In Vitro Culture of Phytomonas Sp. Isolated from Euphorbia characias. Metabolic Studies by 1H NMR

MANUEL SÁNCHEZ-MORENO, CARMEN FERNANDEZ-BECERRA, EMILIO ENTRALA, FRED R. OPPERDOES, MICHEL DOLLET, ANTONIO OSUNA

Journal:

Journal of Eukaryotic Microbiology

Year:

1995

Language:

english

File:

PDF, 1.30 MB

english, 1995

25

Comparative Aspects of Energy Metabolism in Plant Trypanosomatids

CARMEN FERNÁNDEZ-BECERRA, MANUEL SÁNCHEZ-MORENO, ANTONIO OSUNA, FRED R. OPPERDOES

Journal:

Journal of Eukaryotic Microbiology

Year:

1997

Language:

english

File:

PDF, 632 KB

english, 1997

26

Comparative studies on the biochemical properties of the malic enzymes from Trypanosoma cruzi and Trypanosoma brucei

Alejandro E. Leroux, Dante A. Maugeri, Fred R. Opperdoes, Juan J. Cazzulo, Cristina Nowicki

Journal:

FEMS Microbiology Letters

Year:

2011

Language:

english

File:

PDF, 323 KB

english, 2011

27

6-Phosphofructo-2-kinase and fructose-2,6-bisphosphatase in Trypanosomatidae : Molecular characterization, database searches, modelling studies and evolutionary analysis

Nathalie Chevalier, Luc Bertrand, Mark H. Rider, Fred R. Opperdoes, Daniel J. Rigden, Paul A. M. Michels

Journal:

Year:

2005

Language:

english

File:

PDF, 621 KB

english, 2005

28

New approach to screening drugs for activity against African trypanosomes

FAIRLAMB, ALAN H., OPPERDOES, FRED R., BORST, PIET

Journal:

Year:

1977

File:

PDF, 219 KB

1977

29

Macrophage Activation by Polymeric Nanoparticles of Polyalkylcyanoacrylates: Activity Against IntracellularLeishmania donovaniAssociated with Hydrogen Peroxide Production

Rogério Gaspar, Veronique Préat, Fred R. Opperdoes, Michel Roland

Journal:

Pharmaceutical Research

Year:

1992

File:

PDF, 1.09 MB

1992

30

A rapid method for the isolation of intact glycosomes from Trypanosoma brucei by Percoll®-gradient centrifugation in a vertical rotor

Fred R. Opperdoes

Journal:

Molecular and Biochemical Parasitology

Year:

1981

Language:

english

File:

PDF, 290 KB

english, 1981

31

Localization of malate dehydrogenase, adenylate kinase and glycolytic enzymes in glycosomes and the threonine pathway in the mitochondrion of cultured procyclic trypomastigotes of Trypanosoma brucei

Fred R. Opperdoes, Anton Markoš, Rolf F. Steiger

Journal:

Molecular and Biochemical Parasitology

Year:

1981

Language:

english

File:

PDF, 1.06 MB

english, 1981

32

Localization of hydrolases in cultured procyclic trypomastigotes of Trypanosoma brucei

Fred R. Opperdoes, Rolf F. Steiger

Journal:

Molecular and Biochemical Parasitology

Year:

1981

Language:

english

File:

PDF, 702 KB

english, 1981

33

Involvement of lysosomes in the uptake of macromolecular material by bloodstream forms of Trypanosoma brucei

Fred R. Opperdoes, Joris Van Roy

Journal:

Molecular and Biochemical Parasitology

Year:

1982

Language:

english

File:

PDF, 637 KB

english, 1982

34

The phospholipases of Trypanosoma brucei bloodstream forms and cultured procyclics

Fred R. Opperdoes, Joris Van Roy

Journal:

Molecular and Biochemical Parasitology

Year:

1982

Language:

english

File:

PDF, 592 KB

english, 1982

35

Subcellular distribution of adenylate cyclase, cyclic-AMP phosphodiesterase, protein kinases and phosphoprotein phosphatase in Trypanosoma brucei

Rolf D. Walter, Fred R. Opperdoes

Journal:

Molecular and Biochemical Parasitology

Year:

1982

Language:

english

File:

PDF, 556 KB

english, 1982

36

Subcellular distribution and partial characterization of the cyclic AMP-binding proteins of Trypanosoma brucei

Rafael Rangel-Aldao, Fred R. Opperdoes

Journal:

Molecular and Biochemical Parasitology

Year:

1984

Language:

english

File:

PDF, 586 KB

english, 1984

37

A comparison of the glycosomes (microbodies) isolated from Trypanosoma brucei bloodstream form and cultured procyclic trypomastigotes

David T. Hart, Onno Misset, Steven W. Edwards, Fred R. Opperdoes

Journal:

Molecular and Biochemical Parasitology

Year:

1984

Language:

english

File:

PDF, 593 KB

english, 1984

38

The occurrence of glycosomes (microbodies) in the promastigote stage of four major Leishmania species

David T. Hart, Fred R. Opperdoes

Journal:

Molecular and Biochemical Parasitology

Year:

1984

Language:

english

File:

PDF, 1.26 MB

english, 1984

39

Demonstration of glycosomes (microbodies) in the bodonid flagellate Trypanoplasma borelli (protozoa, kinetoplastida)

Fred R. Opperdoes, Eva Nohynkova, Emile Van Schaftingen, Anne-Marie Lambeir, Marten Veenhuis, Joris Van Roy

Journal:

Molecular and Biochemical Parasitology

Year:

1988

Language:

english

File:

PDF, 1019 KB

english, 1988

40

Characterization of the genes for fructose-bisphosphate aldolase in Trypanosoma brucei

Martine Marchand, Annick Poliszczak, Wendy C. Gibson, Rik.K. Wierenga, Fred R. Opperdoes, Paul A.M. Michels

Journal:

Molecular and Biochemical Parasitology

Year:

1988

Language:

english

File:

PDF, 748 KB

english, 1988

41

Perturbation of sterol biosynthesis by itraconazole and ketoconazole in Leishmania mexicana mexicana infected macrophages

David T. Hart, Wim J. Lauwers, Gustaaf Willemsens, Hugo Vanden Bossche, Fred R. Opperdoes

Journal:

Molecular and Biochemical Parasitology

Year:

1989

Language:

english

File:

PDF, 748 KB

english, 1989

42

Chemostat cultures of Leishmania donovani promastigotes and Trypanosoma brucei procyclic trypomastigotes

Benno H. Ter Kuile, Fred R. Opperdoes

Journal:

Molecular and Biochemical Parasitology

Year:

1991

Language:

english

File:

PDF, 167 KB

english, 1991

43

Chemical modification of fructose bisphosphate aldolase from Trypanosoma brucei compared to aldolase from rabbit muscle and Staphylococcus aureus

Mia Callens, Fred R. Opperdoes

Journal:

Molecular and Biochemical Parasitology

Year:

1991

Language:

english

File:

PDF, 552 KB

english, 1991

44

Characterization of pyruvate kinase of Trypanosoma brucei and its role in the regulation of carbohydrate metabolism

Mia Callens, Douglas A. Kuntz, Fred R. Opperdoes

Journal:

Molecular and Biochemical Parasitology

Year:

1991

Language:

english

File:

PDF, 919 KB

english, 1991

45

Kinetic properties of fructose bisphosphate aldolase from Trypanosoma brucei compared to aldolase from rabbit muscle and Staphylococcus aureus

Mia Callens, Douglas A. Kuntz, Fred R. Opperdoes

Journal:

Molecular and Biochemical Parasitology

Year:

1991

Language:

english

File:

PDF, 683 KB

english, 1991

46

Subcellular distribution of trypanothione reductase in bloodstream and procyclic forms of Trypanosoma brucei

Keith Smith, Fred R. Opperdoes, Alan H. Fairlamb

Journal:

Molecular and Biochemical Parasitology

Year:

1991

Language:

english

File:

PDF, 283 KB

english, 1991

47

Characterization of carbohydrate metabolism and demonstration of glycosomes in a Phytomonas sp. isolated from Euphorbia characias

Manuel Sanchez-Moreno, Demeter Lasztity, Isabelle Coppens, Fred R. Opperdoes

Journal:

Molecular and Biochemical Parasitology

Year:

1992

Language:

english

File:

PDF, 4.27 MB

english, 1992

48

The electrochemical proton gradient in the bloodstream form of Trypanosoma brucei is dependent on the temperature

Benno H. Ter Kuile, Erik A.C. Wiemer, Paul A.M. Michels, Fred R. Opperdoes

Journal:

Molecular and Biochemical Parasitology

Year:

1992

Language:

english

File:

PDF, 561 KB

english, 1992

49

Molecular analysis of the cytosolic and glycosomal glyceraldehyde-3-phosphate dehydrogenase in Leishmania mexicana

Véronique Hannaert, Mieke Blaauw, Linda Kohl, Sylvie Allert, Fred R. Opperdoes, Paul A.M. Michels

Journal:

Molecular and Biochemical Parasitology

Year:

1992

Language:

english

File:

PDF, 955 KB

english, 1992

50

Some kinetic properties of pyruvate kinase from Trypanosoma brucei

Mia Callens, Fred R. Opperdoes

Journal:

Molecular and Biochemical Parasitology

Year:

1992

Language:

english

File:

PDF, 673 KB

english, 1992

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